Imidazopyridazine Hepatitis C Virus Polymerase Inhibitors. Structure–Activity Relationship Studies and the Discovery of a Novel, Traceless Prodrug Mechanism-Reference-Cited by-同舟云学术

Imidazopyridazine Hepatitis C Virus Polymerase Inhibitors. Structure–Activity Relationship Studies and the Discovery of a Novel, Traceless Prodrug Mechanism

Published:2013-11-23 Issue:5 Volume:57 Page:1964-1975
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Leivers Martin¹,Miller John F.¹,Chan Stephanie A.¹,Lauchli Ryan¹,Liehr Sebastian¹²,Mo Wenyan¹³,Ton Tony¹⁴,Turner Elizabeth M.¹,Youngman Michael¹⁵,Falls J. Greg¹,Long Susan¹,Mathis Amanda¹⁶,Walker Jill¹

Affiliation:

1. GlaxoSmithKline Research & Development, 5 Moore Drive, Research Triangle Park, North Carolina 27709, United States

2. Santen Inc., 2100 Powell Street, Suite 1600, Emeryville, California 94608, United States

3. ChemPartner Co., 998 Halei Road, Shanghai 201203, China

4. Principia Biopharma, Inc., 400 East Jamie Court, Suite 302, South San Francisco, California 94080, United States

5. Lieber Institute For Brain Development, 855 North Wolfe Street, Suite 300, Baltimore, Maryland 21205, United States

6. Nonclinical and Clinical Pharmacology, Salix Pharmaceuticals, Inc., 8510 Colonnade Center Drive, Raleigh, North Carolina 27615, United States

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm401337x

Reference30 articles.

1. Hepatitis C Fact Sheet No. 164;World Health Organization (WHO):Geneva,July 2012; http://www.who.int/mediacentre/factsheets/fs164/en/.

2. Treatment of chronic hepatitis C with PEGylated interferon and ribavirin

3. Current therapy and new molecular approaches to antiviral treatment and prevention of hepatitis C

4. Virus-specific mechanisms of carcinogenesis in hepatitis C virus associated liver cancer

5. Replication of Subgenomic Hepatitis C Virus RNAs in a Hepatoma Cell Line

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