Synthesis and Structure−Activity Relationship of Novel 6-Aryl-1,4- dihydrobenzo[d][1,3]oxazine-2-thiones as Progesterone Receptor Modulators Leading to the Potent and Selective Nonsteroidal Progesterone Receptor Agonist Tanaproget-Reference-Cited by-同舟云学术

Synthesis and Structure−Activity Relationship of Novel 6-Aryl-1,4- dihydrobenzo[d][1,3]oxazine-2-thiones as Progesterone Receptor Modulators Leading to the Potent and Selective Nonsteroidal Progesterone Receptor Agonist Tanaproget

Published:2005-07-12 Issue:16 Volume:48 Page:5092-5095
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Fensome Andrew¹,Bender Reinhold¹,Chopra Rajiv¹,Cohen Jeff¹,Collins Mark A.¹,Hudak Valerie¹,Malakian Karl¹,Lockhead Susan¹,Olland Andrea¹,Svenson Kristine¹,Terefenko Eugene A.¹,Unwalla Ray J.¹,Wilhelm James M.¹,Wolfrom Scott¹,Zhu Yuan¹,Zhang Zhiming¹,Zhang Puwen¹,Winneker Richard C.¹,Wrobel Jay¹

Affiliation:

1. Chemical and Screening Sciences, Women's Health Research Institute, and Drug Safety and Metabolism, Wyeth Research, 500 Arcola Road, Collegeville, Pennsylvania 19426

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm050358b

Reference16 articles.

1. Discovery and Preliminary SAR Studies of a Novel, Nonsteroidal Progesterone Receptor Antagonist Pharmacophore

2. In vitro characterization of trimegestone: a new potent and selective progestin

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