3,5-Bis(benzylidene)-1-[3-(2-hydroxyethylthio)propanoyl]piperidin-4-ones: A Novel Cluster of Potent Tumor-Selective Cytotoxins-Reference-Cited by-同舟云学术

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3,5-Bis(benzylidene)-1-[3-(2-hydroxyethylthio)propanoyl]piperidin-4-ones: A Novel Cluster of Potent Tumor-Selective Cytotoxins

Published:2011-04-20 Issue:9 Volume:54 Page:3445-3449
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Das Umashankar¹,Pati Hari N.¹,Sakagami Hiroshi²,Hashimoto Ken²,Kawase Masami³,Balzarini Jan⁴,De Clercq Erik⁴,Dimmock Jonathan R.¹

Affiliation:

1. Drug Design and Discovery Research Group, College of Pharmacy and Nutrition, University of Saskatchewan, Saskatoon, Saskatchewan S7N 5C9, Canada

2. Department of Diagnostic and Therapeutic Sciences, Division of Pharmacology, Meikai University School of Dentistry, Saitama 350-0238, Japan

3. Faculty of Pharmaceutical Sciences, Matsuyama University, 4-2 Bunkyo-cho, Matsuyama, Ehime 790-8578, Japan

4. Rega Institute for Medical Research, Katholieke Universiteit Leuven, B-3000 Leuven, Belgium

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm101595p

Reference18 articles.

1. 1-p-Chlorophenyl-4,4-dimethyl-5-diethylamino-1-penten-3-one hydrobromide, a sulfhydryl-specific compound which reacts irreversibly with protein thiols but reversibly with small molecular weight thiols

2. Degradation and Inactivation of Antitumor Drugs

3. Role of cellular glutathione and glutathione S-transferase in the expression of alkylating agent cytotoxicity in human breast cancer cells

4. Chemosensitization by buthionine sulfoximine in vivo

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1. 1-[4-(2-Dimethylaminoethoxy)phenylcarbonyl]-3,5-Bis(3,4,5-Trimethoxybenzylidene)- 4-Piperidone Hydrochloride and Related Compounds: Potent Cytotoxins Demonstrate Greater Toxicity to Neoplasms than Non- Malignant Cells;Medicinal Chemistry;2022-11

2. Stereochemical, single crystal X-ray structural, Hirshfeld surface and cyclic voltammetric studies of N-cyclohexylcarbamoyl-3-isopropyl-2,6-bis(phenyl)piperidin-4-one and N-cyclohexylcarbamoyl-3,3-dimethyl-2,6-bis(4-fluorophenyl)-piperidin-4-one;Chemical Data Collections;2021-10

3. A One-Pot Three-Component Synthesis and Investigation of the In Vitro Mechanistic Anticancer Activity of Highly Functionalized Spirooxindole-Pyrrolidine Heterocyclic Hybrids;Molecules;2020-11-27

4. Functionalized N-Pyridinylmethyl Engrafted Bisarylmethylidenepyridinones as Anticancer Agents;Processes;2020-09-15

5. Multicomponent Domino Synthesis, Anticancer Activity and Molecular Modeling Simulation of Complex Dispirooxindolopyrrolidines;Molecules;2018-05-05

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