Discovery of the First Potent Inhibitors of Mutant IDH1 That Lower Tumor 2-HG in Vivo-Reference-Cited by-同舟云学术

Discovery of the First Potent Inhibitors of Mutant IDH1 That Lower Tumor 2-HG in Vivo

Published:2012-09-17 Issue:10 Volume:3 Page:850-855
ISSN:1948-5875
Container-title:ACS Medicinal Chemistry Letters
language:en
Short-container-title:ACS Med. Chem. Lett.

Author:

Popovici-Muller Janeta¹,Saunders Jeffrey O.²,Salituro Francesco G.³,Travins Jeremy M.¹,Yan Shunqi⁴,Zhao Fang⁵,Gross Stefan¹,Dang Lenny¹,Yen Katharine E.¹,Yang Hua¹,Straley Kimberly S.¹,Jin Shengfang¹,Kunii Kaiko¹,Fantin Valeria R.⁶,Zhang Shunan⁷,Pan Qiongqun⁷,Shi Derek⁷,Biller Scott A.¹,Su Shinsan M.¹

Affiliation:

1. Agios Pharmaceuticals, 38 Sidney Street, Cambridge, Massachusetts 02139, United States

2. Ember Therapeutics, 855 Boylston Street, 11th Floor, Suite B, Boston, Massachusetts 02116, United States

3. Sage Therapeutics, 215 First Street, Cambridge, Massachusetts 02141, United States

4. Schrödinger, Inc., 120 West 45th Street, New York, New York 10036, United States

5. Sundia MediTech Company, Ltd., Building 8, 388 Jialilue Road, Zhangjiang High-Tech Park, Shanghai 201203, China

6. Oncology Research Unit, Pfizer Worldwide Research and Development, La Jolla Laboratories, San Diego, California 92121, United States

7. Shanghai ChemPartner Co., LTD, 998 Halei Road, Zhangjiang Hi-tech Park, Pudong New Area, Shanghai 201203, China

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/ml300225h

Reference17 articles.

1. Cancer-associated IDH mutations: biomarker and therapeutic opportunities

2. Isocitrate Dehydrogenase 1 and 2 Mutations in Cancer: Alterations at a Crossroads of Cellular Metabolism

3. An Integrated Genomic Analysis of Human Glioblastoma Multiforme

4. IDH1andIDH2Mutations in Gliomas

5. IDH1andIDH2Mutations Are Frequent Genetic Alterations in Acute Myeloid Leukemia and Confer Adverse Prognosis in Cytogenetically Normal Acute Myeloid Leukemia WithNPM1Mutation WithoutFLT3Internal Tandem Duplication

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