Discovery of 4-[(2S)-2-{[4-(4-Chlorophenoxy)phenoxy]methyl}-1-pyrrolidinyl]butanoic Acid (DG-051) as a Novel Leukotriene A4 Hydrolase Inhibitor of Leukotriene B4 Biosynthesis-Reference-Cited by-同舟云学术

Discovery of 4-[(2S)-2-{[4-(4-Chlorophenoxy)phenoxy]methyl}-1-pyrrolidinyl]butanoic Acid (DG-051) as a Novel Leukotriene A4 Hydrolase Inhibitor of Leukotriene B4 Biosynthesis

Published:2009-12-01 Issue:2 Volume:53 Page:573-585
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Sandanayaka Vincent¹,Mamat Bjorn²,Mishra Rama K.¹,Winger Jennifer¹,Krohn Michael¹,Zhou Li-Ming¹,Keyvan Monica¹,Enache Livia¹,Sullins David¹,Onua Emmanuel¹,Zhang Jun¹,Halldorsdottir Gudrun²,Sigthorsdottir Heida²,Thorlaksdottir Audur²,Sigthorsson Gudmundur²,Thorsteinnsdottir Margret²,Davies Douglas R.³,Stewart Lance J.³,Zembower David E.¹,Andresson Thorkell²,Kiselyov Alex S.¹,Singh Jasbir¹,Gurney Mark E.¹²³

Affiliation:

1. Medicinal Chemistry, deCODE Chemistry, Inc., 2501 Davey Road, Woodridge, Illinois 60517

2. Drug Discovery, deCODE Genetics, Sturlgata 8, IS-101, Reykjavik, Iceland

3. deCODE Biostructures, Inc., 7869 NE Day Road West, Bainbridge Island, Washington 98110

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm900838g

Reference58 articles.

1. The gene encoding 5-lipoxygenase activating protein confers risk of myocardial infarction and stroke

2. A variant of the gene encoding leukotriene A4 hydrolase confers ethnicity-specific risk of myocardial infarction

3. Atherosclerosis is an Inflammatory Disorder After All

4. Expanding expression of the 5-lipoxygenase pathway within the arterial wall during human atherogenesis

5. Association Between 5-Lipoxygenase Expression and Plaque Instability in Humans

Cited by 62 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Targeting the GPI transamidase subunit GPAA1 abrogates the CD24 immune checkpoint in ovarian cancer;Cell Reports;2024-04

2. Quantum Mechanical/Molecular Mechanical Elucidation of the Catalytic Mechanism of Leukotriene A4 Hydrolase as an Epoxidase;The Journal of Physical Chemistry B;2023-11-27

3. Inhibiting the GPI Transamidase Subunit GPAA1 Abolishes CD24 Surface Localization and Enhances Macrophage-Mediated Phagocytosis of Ovarian Cancer Cells;2023-10-23

4. Structures of Leukotriene Biosynthetic Enzymes and Development of New Therapeutics;Annual Review of Pharmacology and Toxicology;2023-01-20

5. Fragment-to-Lead Medicinal Chemistry Publications in 2021;Journal of Medicinal Chemistry;2023-01-09