Dibenzosuberones as p38 Mitogen-Activated Protein Kinase Inhibitors with Low ATP Competitiveness and Outstanding Whole Blood Activity-Reference-Cited by-同舟云学术

Dibenzosuberones as p38 Mitogen-Activated Protein Kinase Inhibitors with Low ATP Competitiveness and Outstanding Whole Blood Activity

Published:2012-12-27 Issue:1 Volume:56 Page:241-253
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Fischer Stefan¹,Wentsch Heike K.¹,Mayer-Wrangowski Svenja C.²,Zimmermann Markus¹,Bauer Silke M.¹,Storch Kirsten¹,Niess Raimund¹,Koeberle Solveigh C.¹,Grütter Christian²,Boeckler Frank M.¹,Rauh Daniel²,Laufer Stefan A.¹

Affiliation:

1. Institute of Pharmacy, University of Tübingen, Auf der Morgenstelle 8, D-72076 Tübingen, Germany

2. Chemische Biologie, Fakultät Chemie, Technische Universität Dortmund, Otto-Hahn-Strasse 6, D-44227 Dortmund, Germany

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm301539x

Reference26 articles.

1. p38α mitogen-activated protein kinase inhibitors, a patent review (2005 – 2011)

2. Structure−Activity Relationships of the p38α MAP Kinase Inhibitor 1-(5-tert-Butyl-2-p-tolyl-2H-pyrazol-3-yl)-3-[4-(2-morpholin-4-yl-ethoxy)naph- thalen-1-yl]urea (BIRB 796)

3. A p38 Mitogen-Activated Protein Kinase-Dependent Mechanism of Disinhibition in Spinal Synaptic Transmission Induced by Tumor Necrosis Factor-

4. www.clinicaltrials.gov(accessedMarch 1, 2012), 2012.

5. Evaluation of the efficacy and safety of pamapimod, a p38 MAP kinase inhibitor, in a double-blind, methotrexate-controlled study of patients with active rheumatoid arthritis

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