Limited Proteolysis Combined with Stable Isotope Labeling Reveals Conformational Changes in Protein (Pseudo)kinases upon Binding Small Molecules

Author:

Di Michele Michela12,Stes Elisabeth12,Vandermarliere Elien12,Arora Rohit3,Astorga-Wells Juan4,Vandenbussche Jonathan12,van Heerde Erika5,Zubarev Roman6,Bonnet Pascal3,Linders Joannes T. M.5,Jacoby Edgar5,Brehmer Dirk5,Martens Lennart12,Gevaert Kris12

Affiliation:

1. Department of Medical Protein Research, VIB, A. Baertsoenkaai 3, 9000 Ghent, Belgium

2. Department of Biochemistry, Ghent University, A. Baertsoenkaai 3, 9000 Ghent, Belgium

3. Institut de Chimie Organique et Analytique (ICOA), UMR 7311 CNRS-Université d’Orléans, Pôle de chimie, Rue de Chartres, 45100 Orléans, France

4. Biomotif AB, P.O. Box 156, SE-182 12 Danderyd, Sweden

5. Oncology Discovery, Janssen Research and Development, A Division of Janssen Pharmaceutica NV, Turnhoutseweg 30, B-2340 Beerse, Belgium

6. Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Scheelelaberatoriet Scheeles väg 2, SE-171 77 Stockholm, Sweden

Funder

Janssen Pharmaceutica

Fonds Wetenschappelijk Onderzoek

Agentschap voor Innovatie door Wetenschap en Technologie

Publisher

American Chemical Society (ACS)

Subject

General Chemistry,Biochemistry

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3