Proteomic Analysis of Azacitidine-Induced Degradation Profiles Identifies Multiple Chromatin and Epigenetic Regulators Including Uhrf1 and Dnmt1 as Sensitive to Azacitidine-Reference-Cited by-同舟云学术

Proteomic Analysis of Azacitidine-Induced Degradation Profiles Identifies Multiple Chromatin and Epigenetic Regulators Including Uhrf1 and Dnmt1 as Sensitive to Azacitidine

Published:2019-01-23 Issue:3 Volume:18 Page:1032-1042
ISSN:1535-3893
Container-title:Journal of Proteome Research
language:en
Short-container-title:J. Proteome Res.

Author:

Bowler Emily H¹,Bell Joseph¹,Divecha Nullin¹,Skipp Paul¹,Ewing Rob M.¹^ORCID

Affiliation:

1. School of Biological Sciences, University of Southampton, Southampton SO17 1BJ, United Kingdom

Funder

FP7 People: Marie-Curie Actions

Publisher

American Chemical Society (ACS)

Subject

General Chemistry,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jproteome.8b00745

Reference35 articles.

1. Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals

2. Regulation of DNA methyltransferase 1 by interactions and modifications

3. The DNA Methyltransferase Dnmt1 Directly Interacts with the SET and RING Finger-associated (SRA) Domain of the Multifunctional Protein Uhrf1 to Facilitate Accession of the Catalytic Center to Hemi-methylated DNA

4. UHRF1 targets DNMT1 for DNA methylation through cooperative binding of hemi-methylated DNA and methylated H3K9

5. DNA methylation in breast and colorectal cancers

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