Systemic Perturbations in Amine and Kynurenine Metabolism Associated with Acute SARS-CoV-2 Infection and Inflammatory Cytokine Responses

Author:

Lawler Nathan G.1ORCID,Gray Nicola1ORCID,Kimhofer Torben1ORCID,Boughton Berin1ORCID,Gay Melvin2,Yang Rongchang1,Morillon Aude-Claire1,Chin Sung-Tong1,Ryan Monique1,Begum Sofina13,Bong Sze How1ORCID,Coudert Jerome D.4,Edgar Dale567,Raby Edward89,Pettersson Sven101112,Richards Toby13,Holmes Elaine13ORCID,Whiley Luke114ORCID,Nicholson Jeremy K.11315ORCID

Affiliation:

1. Australian National Phenome Centre, Computational and Systems Medicine, Health Futures Institute, Murdoch University, Harry Perkins Building, Perth, WA 6150, Australia

2. Bruker Pty Ltd., Preston, VIC 3072, Australia

3. Department of Metabolism Digestion and Reproduction, Faculty of Medicine, Imperial College London, Sir Alexander Fleming Building, South Kensington, London SW7 2AZ, U.K.

4. Centre for Molecular Medicine & Innovative Therapeutics, Murdoch University, Perth, WA 6150, Australia

5. State Adult Burn Unit, Fiona Stanley Hospital, Murdoch, WA 6150, Australia

6. Burn Injury Research Node, The University of Notre Dame, Fremantle, WA 6160, Australia

7. Fiona Wood Foundation, Murdoch, WA 6150, Australia

8. Department of Microbiology, PathWest Laboratory Medicine, Perth, WA 6009, Australia

9. Department of Infectious Diseases, Fiona Stanley Hospital, Perth, WA 6150, Australia

10. Singapore National Neuro Science Centre, Singapore Mandalay Road, Singapore 308232, Singapore

11. Lee Kong Chian School of Medicine, Nanyang Technological University, Mandalay Road, Singapore 308232, Singapore

12. Department of Life Science Centre, Sunway University, 55100 Kuala Lumpur, Malaysia

13. Medical School, Faculty of Health and Medical Sciences, University of Western Australia, Nedlands, WA 6009, Australia

14. Perron Institute for Neurological and Translational Science, Nedlands, WA 6009, Australia

15. Institute of Global Health Innovation, Imperial College London, Level 1, Faculty Building South Kensington Campus, London SW7 2AZ, U.K.

Funder

Western Australian State Government

Spinnaker Health Research Foundation

Medical Research Future Fund

The McCusker Foundation

Publisher

American Chemical Society (ACS)

Subject

General Chemistry,Biochemistry

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