Optimization of a GC-MS Injection-Port Derivatization Methodology to Enhance Metabolomics Analysis Throughput in Biological Samples

Author:

Foguet-Romero Elisabet1,Samarra Iris1,Guirro Maria1,Riu Marc1ORCID,Joven Jorge23,Menendez Javier A.45,Canela Núria1ORCID,DelPino-Rius Antoni1,Fernández-Arroyo Salvador1ORCID,Herrero Pol1

Affiliation:

1. Centre for Omic Sciences (Joint Unit Eurecat─Universitat Rovira i Virgili), Unique Scientific and Technical Infrastructure (ICTS), Eurecat, Centre Tecnològic de Catalunya, Avda. De la Universitat, 1, 43204 Reus, Tarragona, Spain

2. Departament de Medicina i Cirurgia, Universitat Rovira i Virgili, 43201 Reus, Spain

3. Institut d′investigació Sanitària Pere Virgili, Hospital Universitari de Sant Joan, Unitat de Recerca Biomèdica, 43204 Reus, Spain

4. Girona Biomedical Research Institute (IdIBGi), Salt, 17190 Girona, Spain

5. Metabolism & Cancer Group, ProCURE, Catalan Institute of Oncology, 17007 Girona, Spain

Funder

Instituto de Salud Carlos III

Ag?ncia de Gesti? d'Ajuts Universitaris i de Recerca

Ag?ncia per a la Competitivitat de l'Empresa

Publisher

American Chemical Society (ACS)

Subject

General Chemistry,Biochemistry

Reference62 articles.

1. Novel methodologies in metabolic profiling with a focus on molecular diagnostic applications

2. FiehnLib: Mass Spectral and Retention Index Libraries for Metabolomics Based on Quadrupole and Time-of-Flight Gas Chromatography/Mass Spectrometry

3. Electron Ionization Library Component of the NIST/EPA/NIH Mass Spectral Library and NIST GC Retention Index Database | NIST. https://www.nist.gov/programs-projects/electron-ionization-library-component-nistepanih-mass-spectral-library-and-nist-gc. (accessed Apr 23, 2021).

4. Metabolomics by Gas Chromatography–Mass Spectrometry: Combined Targeted and Untargeted Profiling

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