Integrated Univariate, Multivariate, and Correlation-Based Network Analyses Reveal Metabolite-Specific Effects on Bacterial Growth and Biofilm Formation in Necrotizing Soft Tissue Infections

Author:

Afzal Muhammad1ORCID,Saccenti Edoardo2ORCID,Madsen Martin Bruun3ORCID,Hansen Marco Bo4ORCID,Hyldegaard Ole3ORCID,Skrede Steinar56ORCID,Martins dos Santos Vitor A. P.2ORCID,Norrby-Teglund Anna1ORCID,Svensson Mattias1ORCID

Affiliation:

1. Center for Infectious Medicine, Department of Medicine, ANA Futura, Karolinska Institutet, Karolinska University Hospital, Alfred Nobels Allé 8, 141 52 Huddinge, Sweden

2. Laboratory of Systems and Synthetic Biology, Wageningen University & Research, Stippeneng 4, Wageningen 6708 WE, The Netherlands

3. Department of Intensive Care, Copenhagen University Hospital, Rigshospitalet, Copenhagen 2100, Denmark

4. Hyperbaric Unit, Department of Anesthesia, Center of Head and Orthopedics, Rigshospitalet, University of Copenhagen, Blegdamsvej 9, Copenhagen DK-2100, Denmark

5. Department of Medicine, Haukeland University Hospital, Bergen N-5021, Norway

6. Department of Clinical Science, University of Bergen, Bergen N-5020, Norway

Funder

Vetenskapsrådet

Seventh Framework Programme

Publisher

American Chemical Society (ACS)

Subject

General Chemistry,Biochemistry

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