Molecular Basis of Substrate Promiscuity for the SAM-Dependent O-Methyltransferase NcsB1, Involved in the Biosynthesis of the Enediyne Antitumor Antibiotic Neocarzinostatin-Reference-Cited by-同舟云学术

Molecular Basis of Substrate Promiscuity for the SAM-Dependent O-Methyltransferase NcsB1, Involved in the Biosynthesis of the Enediyne Antitumor Antibiotic Neocarzinostatin

Published:2009-09-16 Issue:40 Volume:48 Page:9590-9598
ISSN:0006-2960
Container-title:Biochemistry
language:en
Short-container-title:Biochemistry

Author:

Cooke Heather A.¹,Guenther Elizabeth L.¹,Luo Yinggang²,Shen Ben²³,Bruner Steven D.¹

Affiliation:

1. Department of Chemistry, Merkert Chemistry Center, Boston College, Chestnut Hill, Massachusetts 02467

2. Division of Pharmaceutical Sciences

3. Department of Chemistry

Publisher

American Chemical Society (ACS)

Subject

Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/bi901257q

Reference48 articles.

1. Enediyne Natural Products: Biosynthesis and Prospect Towards Engineering Novel Antitumor Agents

2. Rapid PCR amplification of minimal enediyne polyketide synthase cassettes leads to a predictive familial classification model

3. The Neocarzinostatin Biosynthetic Gene Cluster from Streptomyces carzinostaticus ATCC 15944 Involving Two Iterative Type I Polyketide Synthases

4. Genome sequencing reveals complex secondary metabolome in the marine actinomycete Salinispora tropica

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