Thienopyrimidine Bisphosphonate (ThPBP) Inhibitors of the Human Farnesyl Pyrophosphate Synthase: Optimization and Characterization of the Mode of Inhibition-Reference-Cited by-同舟云学术

Thienopyrimidine Bisphosphonate (ThPBP) Inhibitors of the Human Farnesyl Pyrophosphate Synthase: Optimization and Characterization of the Mode of Inhibition

Published:2013-10-03 Issue:20 Volume:56 Page:7939-7950
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Leung Chun Yuen¹,Park Jaeok²,De Schutter Joris W.¹,Sebag Michael³,Berghuis Albert M.¹²⁴,Tsantrizos Youla S.¹²⁵

Affiliation:

1. Department of Chemistry, McGill University, 801 Sherbrooke Street West, Montreal, Quebec, Canada H3A 0B8

2. Department of Biochemistry, McGill University, 3649 Promenade Sir William Osler, Montreal, Quebec, Canada H3G 0B1

3. Division of Haematology, McGill University Health Center, Royal Victoria Hospital, C6.80, 687 Pine Avenue West, Montreal, Quebec, Canada H3A 1A1

4. Department of Microbiology and Immunology, McGill University, 801 Sherbrooke Street West, Montreal, Quebec, Canada H3A 0B8

5. Groupe de Recherche Axé sur la Structure des Protéines, McGill University, 3649 Promenade Sir William Osler, Montreal, Quebec, Canada H3G 0B1

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm400946f

Reference73 articles.

1. Recent advances in understanding the mechanism of action of bisphosphonates

2. Initial genome sequencing and analysis of multiple myeloma

3. Clinical Features of Metastatic Bone Disease and Risk of Skeletal Morbidity

4. How Do Bisphosphonates Inhibit Bone Metastasis In Vivo

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