Optimization of Drug-Like Properties of Nonsteroidal Glucocorticoid Mimetics and Identification of a Clinical Candidate-Reference-Cited by-同舟云学术

Optimization of Drug-Like Properties of Nonsteroidal Glucocorticoid Mimetics and Identification of a Clinical Candidate

Published:2014-11-20 Issue:12 Volume:5 Page:1318-1323
ISSN:1948-5875
Container-title:ACS Medicinal Chemistry Letters
language:en
Short-container-title:ACS Med. Chem. Lett.

Author:

Harcken Christian¹,Riether Doris¹,Liu Pingrong¹,Razavi Hossein¹,Patel Usha¹,Lee Thomas¹,Bosanac Todd¹,Ward Yancey¹,Ralph Mark¹,Chen Zhidong¹,Souza Donald¹,Nelson Richard M.¹,Kukulka Alison¹,Fadra-Khan Tazmeen N.¹,Zuvela-Jelaska Ljiljana¹,Patel Mita¹,Thomson David S.¹,Nabozny Gerald H.¹

Affiliation:

1. Department of Medicinal Chemistry and Department of Immunology and Inflammation, Boehringer Ingelheim Pharmaceuticals, Inc., 900 Ridgebury Road, Ridgefield, Connecticut 06877, United States

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/ml500387y

Reference23 articles.

1. The molecular basis for the effectiveness, toxicity, and resistance to glucocorticoids: focus on the treatment of rheumatoid arthritis

2. Mechanisms involved in the side effects of glucocorticoids

3. Glucocorticoid-Induced Bone Disease

4. The human glucocorticoid receptor: One gene, multiple proteins and diverse responses

5. Molecular Mechanisms of Glucocorticosteroid Actions

Cited by 19 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Palladium-catalyzed cyclization borylmethylation: Access to boryl-functionalized benzene-fused heterocycle compounds;Tetrahedron Letters;2024-09

2. Selective Glucocorticoid Receptor Modulators;SpringerBriefs in Molecular Science;2023

3. The Bifunctional Silyl Reagent Me ₂ (CH ₂ Cl)SiCF ₃ Enables Highly Enantioselective Ketone Trifluoromethylation and Related Tandem Processes;Angewandte Chemie International Edition;2022-08-10

4. The Bifunctional Silyl Reagent Me ₂ (CH ₂ Cl)SiCF ₃ Enables Highly Enantioselective Ketone Trifluoromethylation and Related Tandem Processes;Angewandte Chemie;2022-08-10

5. Direct C–H-sulfonylation of 6-membered nitrogen-heteroaromatics;Tetrahedron Chem;2022-03