Conformationally-LockedN-Glycosides with Selective β-Glucosidase Inhibitory Activity: Identification of a New Non-Iminosugar-Type Pharmacological Chaperone for Gaucher Disease

Author:

Castilla Javier1,Rísquez Rocío2,Cruz Deysi1,Higaki Katsumi3,Nanba Eiji3,Ohno Kousaku4,Suzuki Yoshiyuki5,Díaz Yolanda1,Ortiz Mellet Carmen2,García Fernández José M.6,Castillón Sergio1

Affiliation:

1. Department de Química Analítica i Química Orgànica, Universitat Rovira i Virgili, C/Marcel·lí Domingo s/n, 43007 Tarragona, Spain

2. Departamento de Química Orgánica, Facultad de Química, Universidad de Sevilla, C/Profesor García González 1, 41012 Sevilla, Spain

3. Division of Functional Genomics, Research Center for Bioscience and Technology, Faculty of Medicine, Tottori University, 86 Nishi-cho, Yonago, 683-8503, Japan

4. Division of Child Neurology, Insitute of Neurological Sciences, Faculty of Medicine, Tottori University, Nishi-cho, Yonago, 683-8504, Japan

5. International University of Health and Welfare Graduate School, 2600-1 Kita Kanemaru, Otawara 324-8501, Japan

6. Instituto de Investigaciones Químicas (IIQ), CSIC, Universidad de Sevilla, C/Américo Vespucio 49, Isla de la Cartuja, 41092 Sevilla, Spain

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

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