Novel Selective Inhibitors of the Zinc Plasmodial Aminopeptidase PfA-M1 as Potential Antimalarial Agents

Author:

Flipo Marion1,Beghyn Terence1,Leroux Virginie1,Florent Isabelle1,Deprez Benoit P.1,Deprez-Poulain Rebecca F.1

Affiliation:

1. Inserm, U761, Biostructures and Drug Discovery, Lille F-59006 France, Faculté de Pharmacie, Université de Lille2, Lille F-59006 France, Institut Pasteur de Lille, Lille F-59019 France, and USM504/EA3335 Muséum National d'Histoire Naturelle, Regulations, Development, Molecular diversity, Paris, F-75005 France

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Reference46 articles.

1. 1.3 million deaths in 2004 (World Health Organization Global report 2004, Geneva, 2004), 3 billion people at risk in 2005 (Word Malaria Report 2005 from Roll Back Malaria Partnership, available at www.rbm.who.int/wmr2005/).

2. Antimalarial treatment with artemisinin combination therapy in Africa

3. Resisting resistance: dealing with the irrepressible problem of malaria

4. Economic Implications of Resistance to Antimalarial Drugs

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