1. Department of Medical Genome Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Bioscience Building 702, 5-1-5 Kashiwanoha, Kashiwa, Chiba 277-8562, Japan, and Department of Medicinal and Life Schience, Faculty of Pharmaceutical Sciences, Tokyo University of Science 2641, Yamazaki, Noda, Chiba 278-8510, Japan