Activation and Inhibition of Thermosensitive TRP Channels by Voacangine, an Alkaloid Present in Voacanga africana, an African Tree

Author:

Terada Yuko1,Horie Syunji2,Takayama Hiromitsu3,Uchida Kunitoshi4,Tominaga Makoto4,Watanabe Tatsuo1

Affiliation:

1. Graduate School of Nutritional and Environmental Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka 422-8526, Japan

2. Laboratory of Pharmacology, Faculty of Pharmaceutical Sciences, Josai International University, 1 Gumyo Togane, Chiba 283-8555, Japan

3. Department of Biofunctional Molecular Chemistry, Graduate School of Pharmaceutical Sciences, Chiba University, 1-33 Yayoi-cho, Inage-ku, Chiba 263-8522, Japan

4. Division of Cell Signaling, Okazaki Institute for Integrative Bioscience, National Institutes of Natural Sciences, Higashiyama 5-1, Myodaiji, Okazaki, Aichi 444-8787, Japan

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Complementary and alternative medicine,Drug Discovery,Pharmaceutical Science,Pharmacology,Molecular Medicine,Analytical Chemistry

Reference38 articles.

1. Bouquet, A.; Debray, M.InPlant Medicinals de la Cote d’Ivoire;Office de la Recherche Scientifique et Technique d’Outre Mer (ORSTOM):Paris, 1974; Vol.165, 11, pp38–39.

2. Adjanohoun, J. E.; Aboubakar, N.; Dramane, K.; Ebot, M. E.; Ekpere, J. A.; Enow-Orock, E. G.; Focho, D.; Gbile, Z. O.; Kamanyi, A.; Kamsu-Kom, J.; Keita, A.; Mbenkum, T.; Mbi, C. N.; Mbiele, A. L.; Mbome, L. L.; Mubiru, N. K.; Nancy, W. L.; Nkongmeneck, B.; Satabie, B.; Sofowara, A.; Tamze, V.; Wirmum, C. K.InTraditional Medicine and Pharmacopoeia: Contribution to Ethnobotanical and Florisic Studies in Cameroon;Organization of Africa Unity Scientific, Technical and Research Commision (OUA/STRC), Centre Nationale de Production de Mauels Scolaires:Porto-Novo, Benin, 1996; p63.

3. Screening of some African medicinal plants for antiulcerogenic activity: Part 1

4. Anti-ulcer actions of the bark methanol extract of Voacanga africana in different experimental ulcer models in rats

5. The capsaicin receptor: a heat-activated ion channel in the pain pathway

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