Statistical Design for Biospecimen Cohort Size in Proteomics-based Biomarker Discovery and Verification Studies

Author:

Skates Steven J.1,Gillette Michael A.2,LaBaer Joshua3,Carr Steven A.2,Anderson Leigh45,Liebler Daniel C.6,Ransohoff David7,Rifai Nader8910,Kondratovich Marina11,Težak Živana11,Mansfield Elizabeth11,Oberg Ann L.12,Wright Ian5,Barnes Grady13,Gail Mitchell14,Mesri Mehdi15,Kinsinger Christopher R.15,Rodriguez Henry15,Boja Emily S.15

Affiliation:

1. Biostatistics Center, Massachusetts General Hospital Cancer Center, Boston, Massachusetts 02114, United States

2. Proteomics Platform, Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, Massachusetts 02142, United States

3. Personalized Diagnostics, The Biodesign Institute, Arizona State University, Tempe, Arizona 85287, United States

4. The Plasma Proteome Institute, Washington, D.C. 20009, United States

5. SISCAPA Technologies, Inc., Washington, D.C. 20009, United States

6. Jim Ayers Institute for Precancer Detection and Diagnosis and Department of Biochemistry, Vanderbilt University, School of Medicine, Nashville, Tennessee 37232, United States

7. Division of Gastroenterology and Hepatology, Department of Medicine, University of North Carolina, Chapel Hill, North Carolina 27514, United States

8. Department of Laboratory Medicine, Children’s Hospital Boston, Boston, Massachusetts 02115, United States

9. Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, United States

10. King Abdulaziz University, Jeddah 22254, Saudi Arabia

11. Office of In Vitro Diagnostics and Radiological Health, Center for Devices and Radiological Health, Food and Drug Administration, Department of Health and Human Services, Silver Spring, Maryland 20993, United States

12. Division of Biomedical Statistics and Informatics, Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota 55905, United States

13. Fujirebio Diagnostics, Inc., Malvern, Pennsylvania 19355, United States

14. Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health & Human Services, Bethesda, Maryland 20892, United States

15. Office of Cancer Clinical Proteomics Research, Center for Strategic Scientific Initiatives, National Cancer Institute, National Institutes of Health, Department of Health & Human Services, Bethesda, Maryland 20892, United States

Publisher

American Chemical Society (ACS)

Subject

General Chemistry,Biochemistry

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