The Glutamine Side Chain at Position 91 on the β5a−β5b Loop of Human Immunodeficiency Virus Type 1 Reverse Transcriptase Is Required for Stabilizing the dNTP Binding Pocket-Reference-Cited by-同舟云学术

The Glutamine Side Chain at Position 91 on the β5a−β5b Loop of Human Immunodeficiency Virus Type 1 Reverse Transcriptase Is Required for Stabilizing the dNTP Binding Pocket

Published:2011-08-23 Issue:37 Volume:50 Page:8067-8077
ISSN:0006-2960
Container-title:Biochemistry
language:en
Short-container-title:Biochemistry

Author:

Pandey Nootan¹,Mishra Chaturbhuj A.¹,Manvar Dinesh¹,Upadhyay Alok K.¹,Talele Tanaji T.²,Comollo Thomas W.¹,Kaushik-Basu Neerja¹,Pandey Virendra N.¹

Affiliation:

1. Department of Biochemistry and Molecular Biology, University of Medicine and Dentistry of New Jersey Medical School, 185 South Orange Avenue, Newark, New Jersey 07103, United States

2. Department of Pharmaceutical Sciences, College of Pharmacy and Allied Health Professions, St. John's University, 8000 Utopia Parkway, Queens, New York 11439, United States

Publisher

American Chemical Society (ACS)

Subject

Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/bi200815e

Reference67 articles.

1. Viral dynamics in human immunodeficiency virus type 1 infection

2. Rapid turnover of plasma virions and CD4 lymphocytes in HIV-1 infection

3. Structures of HIV-1 RT–DNA complexes before and after incorporation of the anti-AIDS drug tenofovir

4. Structural Basis for the Role of the K65R Mutation in HIV-1 Reverse Transcriptase Polymerization, Excision Antagonism, and Tenofovir Resistance

5. Mechanism of inhibition of HIV-1 reverse transcriptase by non-nucleoside inhibitors

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1. A Novel Leu92 Mutant of HIV-1 Reverse Transcriptase with a Selective Deficiency in Strand Transfer Causes a Loss of Viral Replication;Journal of Virology;2015-05-20