Looking-Glass Synergistic Pharmacological Chaperones: DGJ and L-DGJ from the Enantiomers of Tagatose-Reference-Cited by-同舟云学术

Looking-Glass Synergistic Pharmacological Chaperones: DGJ and L-DGJ from the Enantiomers of Tagatose

Published:2011-07-11 Issue:15 Volume:13 Page:4064-4067
ISSN:1523-7060
Container-title:Organic Letters
language:en
Short-container-title:Org. Lett.

Author:

Jenkinson Sarah F.¹,Fleet George W. J.¹,Nash Robert J.¹,Koike Yuriko¹,Adachi Isao¹,Yoshihara Akihide¹,Morimoto Kenji¹,Izumori Ken¹,Kato Atsushi¹

Affiliation:

1. Chemistry Research Laboratory, Department of Chemistry, University of Oxford, Mansfield Road, OX1 3TA, United Kingdom, Oxford Glycobiology Institute, University of Oxford, South Parks Road, Oxford, OX1 3QU, United Kingdom, Phytoquest Limited, Plas Gogerddan Aberystwyth, Ceredigion, SY23 3EB, United Kingdom, Department of Hospital Pharmacy, University of Toyama, Toyama 930-0194, Japan, and Rare Sugar Research Center, Kagawa University, 2393 Ikenobe, Miki-cho, Kita-gun, Kagawa 761-0795, Japan

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/ol201552q

Reference44 articles.

1. Biological Properties of d- and l-1-Deoxyazasugars

2. Looking glass inhibitors: efficient synthesis and biological evaluation of d-deoxyfuconojirimycin

3. Looking glass inhibitors: scalable syntheses of DNJ, DMDP, and (3R)-3-hydroxy-l-bulgecinine from d-glucuronolactone and of l-DNJ, l-DMDP, and (3S)-3-hydroxy-d-bulgecinine from l-glucuronolactone. DMDP inhibits β-glucosidases and β-galactosidases whereas l-DMDP is a potent and specific inhibitor of α-glucosidases

4. Potent competitive inhibition of α-galactosidase and α-glucosidase activity by 1,4-dideoxy-1,4-iminopentitols: syntheses of 1,4-dideoxy-1,4-imino-d-lyxitol and of both enantiomers of 1,4-dideoxy-1,4-iminoarabinitol

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