Prediction and Validation of a Protein’s Free Energy Surface Using Hydrogen Exchange and (Importantly) Its Denaturant Dependence-Reference-Cited by-同舟云学术

Prediction and Validation of a Protein’s Free Energy Surface Using Hydrogen Exchange and (Importantly) Its Denaturant Dependence

Published:2021-12-22 Issue:1 Volume:18 Page:550-561
ISSN:1549-9618
Container-title:Journal of Chemical Theory and Computation
language:en
Short-container-title:J. Chem. Theory Comput.

Author:

Peng Xiangda¹,Baxa Michael¹,Faruk Nabil²,Sachleben Joseph R.³,Pintscher Sebastian¹⁴^ORCID,Gagnon Isabelle A.¹,Houliston Scott⁵⁶,Arrowsmith Cheryl H.⁵⁶^ORCID,Freed Karl F.⁷^ORCID,Rocklin Gabriel J.⁸^ORCID,Sosnick Tobin R.¹^ORCID

Affiliation:

1. Department of Biochemistry and Molecular Biology, University of Chicago, Chicago, Illinois 60637, United States

2. Graduate Program in Biophysical Sciences, University of Chicago, Chicago, Illinois 60637, United States

3. Division of Biological Sciences, University of Chicago, Chicago, Illinois 60637, United States

4. Department of Molecular Biophysics, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Kraków 30387, Poland

5. Structural Genomics Consortium, University of Toronto, Toronto, Ontario M5G 1L7, Canada

6. Princess Margaret Cancer Centre and Department of Medical Biophysics, University of Toronto, Toronto, Ontario M5G 2M9, Canada

7. Department of Chemistry, University of Chicago, Chicago, Illinois 60637, United States

8. Department of Pharmacology & Center for Synthetic Biology, Northwestern University, Chicago, Illinois 60614, United States

Funder

Division of Molecular and Cellular Biosciences

National Institute of General Medical Sciences

Princess Margaret Cancer Centre, University Health Network

Publisher

American Chemical Society (ACS)

Subject

Physical and Theoretical Chemistry,Computer Science Applications

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jctc.1c00960

Reference49 articles.

1. From protein folding to protein function and biomolecular binding by energy landscape theory

2. Guanidinium Chloride Induction of Partial Unfolding in Amide Proton Exchange in RNase A

3. Protein Folding Intermediates: Native-State Hydrogen Exchange

4. Ensemble modulation as an origin of denaturant-independent hydrogen exchange in proteins 1 1Edited by I. Wilson

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