Required Buried α-Helical Structure in the Bilirubin UDP-Glucuronosyltransferase, UGT1A1, Contains a Nonreplaceable Phenylalanine-Reference-Cited by-同舟云学术

Required Buried α-Helical Structure in the Bilirubin UDP-Glucuronosyltransferase, UGT1A1, Contains a Nonreplaceable Phenylalanine

Published:1998-07-16 Issue:31 Volume:37 Page:11018-11025
ISSN:0006-2960
Container-title:Biochemistry
language:en
Short-container-title:Biochemistry

Author:

Ciotti Marco¹,Cho Jeong W.¹,George John¹,Owens Ida S.¹

Affiliation:

1. Human Genetics Branch, National Institute of Child Health and Human Development, National Institutes of Health, and Laboratory of Molecular Immunology, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892

Publisher

American Chemical Society (ACS)

Subject

Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/bi980747q

Reference29 articles.

1. Roy Chowdhury, J., Wolkoff, A. W., Roy Chowdhury, N., and Arias, I. M. (1995) inThe Metabolic Basis of Inherited Disease(Scriver, C. R., Beaudet, A. L., Sly, W. S., and Valle, D., Eds.) 7th ed., Vol. II, pp 2161−2208, McGraw-Hill Book Co., New York.

2. Identification of a genetic alteration in the code for bilirubin UDP-glucuronosyltransferase in the UGT1 gene complex of a Crigler-Najjar type I patient.

3. Cloning of two human liver bilirubin UDP-glucuronosyltransferase cDNAs with expression in COS-1 cells.

4. A novel complex locus UGT1 encodes human bilirubin, phenol, and other UDP-glucuronosyltransferase isozymes with identical carboxyl termini.

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