Purification of Difluoromethylornithine by Global Process Optimization: Coupling of Chemistry and Chromatography with Enantioselective Crystallization-Reference-Cited by-同舟云学术

Purification of Difluoromethylornithine by Global Process Optimization: Coupling of Chemistry and Chromatography with Enantioselective Crystallization

Published:2007-09-01 Issue:5 Volume:11 Page:817-824
ISSN:1083-6160
Container-title:Organic Process Research & Development
language:en
Short-container-title:Org. Process Res. Dev.

Author:

Perrin Scott R.¹,Hauck Wilhelm¹,Ndzie Elias¹,Blehaut Jean¹,Ludemann-Hombouger Olivier¹,Nicoud Roger-Marc¹,Pirkle William H.¹

Affiliation:

1. NOVASEP, Inc., 23 Creek Circle, Boothwyn, Pennsylvania 19061, Novartis Pharma AG, Litchstrasse 35, CH-4056, Basel, Switzerland, NOVASEP SAS, Site Eiffel, Boulevard de la Moselle, F54340, Pompey, France, and School of Chemical Sciences, University of Illinois, Urbana, Illinois 61801, U.S.A.

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/op700118m

Reference28 articles.

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2. Bey, P.; Jung, M.;2-Halomethyl derivatives of 2-aminoacids. U.S. Patent 4,743,691, 1988.

3. Bey, P.; Jung, M.;2-(Difluoromethyl)-2,5-diaminopentanoicacid, U.S. Patent 4,413,141, 1982.

4. Catalytic irreversible inhibition of mammalian ornithine decarboxylase (E.C.4.1.1.17) by substrate and product analogs

5. Polyamines and cancer: old molecules, new understanding

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