Resistance-Modifying Agents. 11. Pyrimido[5,4-d]pyrimidine Modulators of Antitumor Drug Activity. Synthesis and Structure−Activity Relationships for Nucleoside Transport Inhibition and Binding to α1-Acid Glycoprotein-Reference-Cited by-同舟云学术

Resistance-Modifying Agents. 11. Pyrimido[5,4-d]pyrimidine Modulators of Antitumor Drug Activity. Synthesis and Structure−Activity Relationships for Nucleoside Transport Inhibition and Binding to α1-Acid Glycoprotein

Published:2004-08-26 Issue:20 Volume:47 Page:4905-4922
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Curtin Nicola J.¹,Barlow Hannah C.¹,Bowman Karen J.¹,Calvert A. Hilary¹,Davison Richard¹,Golding Bernard T.¹,Huang Bing¹,Loughlin Peter J.¹,Newell David R.¹,Smith Peter G.¹,Griffin Roger J.¹

Affiliation:

1. Northern Institute for Cancer Research, School of Natural SciencesChemistry, Bedson Building, University of Newcastle upon Tyne, Newcastle upon Tyne NE1 7RU, U.K., and Northern Institute for Cancer Research, Paul O'Gorman Building, Medical School, University of Newcastle upon Tyne, Framlington Place, Newcastle upon Tyne NE2 4HH, U.K.

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm040772w

Reference44 articles.

1. Efficacy, tolerability and management of raltitrexed (Tomudex™) monotherapy in patients with advanced colorectal cancer

2. Phase I Clinical and Pharmacokinetic Study of Pemetrexed and Carboplatin in Patients With Malignant Pleural Mesothelioma

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