Thermally Robust Solvent-Free Liquid Polyplexes for Heat-Shock Protection and Long-Term Room Temperature Storage of Therapeutic Nucleic Acids

Author:

Chen Yiyan1,Lin Xiaoyan1,Liu Xuhan12,Liu Yifan1,Bui-Le Liem1,Blakney Anna K.34ORCID,Yeow Jonathan5ORCID,Zhu Yunqing6ORCID,Stevens Molly M.5ORCID,Shattock Robin J.3,Chen Rongjun1ORCID,Brogan Alex P. S.7ORCID,Hallett Jason P.1ORCID

Affiliation:

1. Department of Chemical Engineering, Imperial College London, Exhibition Road, London SW7 2AZ, U.K.

2. Shenzhen University General Hospital, Shenzhen University Clinical Medical Academy, Shenzhen University, No. 1098 Xueyuan Avenue, Shenzhen 518000, P. R. China

3. Department of Infectious Disease, Imperial College London, Norfolk Place, London W2 1NY, U.K.

4. School of Biomedical Engineering, Michael Smith Laboratories, 2185 East Mall, Vancouver, British Columbia V6T 1Z4, Canada

5. Department of Materials, Department of Bioengineering, and Institute of Biomedical Engineering at Imperial College London, Prince Consort Rd, SW7 2AZ London, South Kensington, U.K.

6. School of Materials Science and Engineering, Tongji University, Shanghai 200092, China

7. Department of Chemistry, King’s College London, 7 Trinity Street, London SE1 1DB, U.K.

Funder

Engineering and Physical Sciences Research Council

Department of Health and Social Care

H2020 Marie Sklodowska-Curie Actions

UK Regenerative Medicine Platform

Publisher

American Chemical Society (ACS)

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