Chemistry and Behavioral Studies Identify Chiral Cyclopropanes as Selective α4β2-Nicotinic Acetylcholine Receptor Partial Agonists Exhibiting an Antidepressant Profile-Reference-Cited by-同舟云学术

Chemistry and Behavioral Studies Identify Chiral Cyclopropanes as Selective α4β2-Nicotinic Acetylcholine Receptor Partial Agonists Exhibiting an Antidepressant Profile

Published:2012-01-10 Issue:2 Volume:55 Page:717-724
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Zhang Hankun¹,Tückmantel Werner²,Eaton J. Brek³,Yuen Po-wai²,Yu Li-Fang¹,Bajjuri Krishna Mohan¹,Fedolak Allison²,Wang Daguang²,Ghavami Afshin²,Caldarone Barbara²,Paterson Neil E.²,Lowe David A.²,Brunner Daniela²,Lukas Ronald J.³,Kozikowski Alan P.¹

Affiliation:

1. Drug Discovery Program, Department of Medicinal Chemistry and Pharmacognosy, University of Illinois at Chicago, 833 South Wood Street, Chicago, Illinois 60612, United States

2. PsychoGenics, Inc., 765 Old Saw Mill River Road, Tarrytown, New York 10591, United States

3. Division of Neurobiology, Barrow Neurological Institute, 350 West Thomas Road, Phoenix, Arizona 85013, United States

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm201157c

Reference37 articles.

1. Design of Ligands for the Nicotinic Acetylcholine Receptors:The Quest for Selectivity

2. Neuronal Nicotinic Acetylcholine Receptors: Structural Revelations, Target Identifications, and Therapeutic Inspirations

3. Central Nicotinic Receptors: Structure, Function, Ligands, and Therapeutic Potential