Synthesis of a Series of Potent and Orally Bioavailable Thrombin Inhibitors That Utilize 3,3-Disubstituted Propionic Acid Derivatives in the P3 Position-Reference-Cited by-同舟云学术

Synthesis of a Series of Potent and Orally Bioavailable Thrombin Inhibitors That Utilize 3,3-Disubstituted Propionic Acid Derivatives in the P3 Position

Published:1997-10-01 Issue:22 Volume:40 Page:3687-3693
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Tucker Thomas J.¹,Lumma William C.¹,Lewis S. Dale¹,Gardell Stephen J.¹,Lucas Bobby J.¹,Sisko Jack T.¹,Lynch Joseph J.¹,Lyle Elizabeth A.¹,Baskin Elizabeth P.¹,Woltmann Richard F.¹,Appleby Sandra D.¹,Chen I-Wu¹,Dancheck Kimberley B.¹,Naylor-Olsen Adel M.¹,Krueger Julie A.¹,Cooper Carolyn M.¹,Vacca Joseph P.¹

Affiliation:

1. Departments of Medicinal Chemistry, Biological Chemistry, General Pharmacology, Drug Metabolism, and Molecular Design and Diversity, Merck Research Laboratories, West Point, Pennsylvania 19486

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm970397q

Reference6 articles.

1. Active site-directed synthetic thrombin inhibitors: synthesis, in vitro and in vivo activity profile of BMY 44621 and analogs. An examination of the role of the amino group in the D-Phe-Pro-Arg-H series

2. Inhibitors of blood platelet aggregation. Activity of some 1H-benz[de]isoquinolinecarboximidamides on the in vivo blood platelet aggregation induced by collagen

3. Cyclic derivatives of 3,3-diphenylalanine (Dip) (II), novel α-amino acids for peptides of biological interest

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