Discovery and Optimization of 1,3,5-Trisubstituted Pyrazolines as Potent and Highly Selective Allosteric Inhibitors of Protein Kinase C-ζ-Reference-Cited by-同舟云学术

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Discovery and Optimization of 1,3,5-Trisubstituted Pyrazolines as Potent and Highly Selective Allosteric Inhibitors of Protein Kinase C-ζ

Published:2014-07-24 Issue:15 Volume:57 Page:6513-6530
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Abdel-Halim Mohammad¹²,Diesel Britta³,Kiemer Alexandra K.³,Abadi Ashraf H.²,Hartmann Rolf W.¹,Engel Matthias¹

Affiliation:

1. Pharmaceutical and Medicinal Chemistry, Saarland University, Campus C2.3, D-66123 Saarbrücken, Germany

2. Department of Pharmaceutical Chemistry, Faculty of Pharmacy and Biotechnology, German University in Cairo, Cairo 11835, Egypt

3. Pharmaceutical Biology, Saarland University, Campus C2.2, D-66123 Saarbrücken, Germany

Funder

German Academic Exchange Service

Deutsche Forschungsgemeinschaft

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm500521n

Reference68 articles.

1. Protein kinase C: poised to signal

2. Of the atypical PKCs, Par-4 and p62: recent understandings of the biology and pathology of a PB1-dominated complex

3. The atypical PKCs in inflammation: NF-κB and beyond

4. Targeted Disruption of the ζPKC Gene Results in the Impairment of the NF-κB Pathway

5. Protein Kinase C-λ Knockout in Embryonic Stem Cells and Adipocytes Impairs Insulin-Stimulated Glucose Transport

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