1. Department of Chemistry, CICECO, University of Aveiro, 3810-193 Aveiro, Portugal, Center for Neuroscience and Cell Biology, Department of Zoology, University of Coimbra, 3004-517 Coimbra, Portugal, and Department of Biochemistry, Faculty of Science and Technology, University of Coimbra, Apartado 3126, 3001-401 Coimbra, Portugal