Discovery and Evaluation of 4-(2-(4-chloro-1H-pyrazol-1-yl)ethylamino)-3-(6-(1-(3-fluoropropyl)piperidin-4-yl)-4-methyl-1H-benzo[d]imidazol-2-yl)pyridin-2(1H)-one (BMS-695735), an Orally Efficacious Inhibitor of Insulin-like Growth Factor-1 Receptor Kinase with Broad Spectrum in Vivo Antitumor Activity-Reference-Cited by-同舟云学术

Discovery and Evaluation of 4-(2-(4-chloro-1H-pyrazol-1-yl)ethylamino)-3-(6-(1-(3-fluoropropyl)piperidin-4-yl)-4-methyl-1H-benzo[d]imidazol-2-yl)pyridin-2(1H)-one (BMS-695735), an Orally Efficacious Inhibitor of Insulin-like Growth Factor-1 Receptor Kinase with Broad Spectrum in Vivo Antitumor Activity

Published:2008-09-03 Issue:19 Volume:51 Page:5897-5900
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Velaparthi Upender¹,Wittman Mark¹,Liu Peiying¹,Carboni Joan M.¹,Lee Francis Y.¹,Attar Ricardo¹,Balimane Praveen¹,Clarke Wendy¹,Sinz Michael W.¹,Hurlburt Warren¹,Patel Karishma¹,Discenza Lorell¹,Kim Sean¹,Gottardis Marco¹,Greer Ann¹,Li Aixin¹,Saulnier Mark¹,Yang Zheng¹,Zimmermann Kurt¹,Trainor George¹,Vyas Dolatrai¹

Affiliation:

1. Discovery Chemistry, Department of Metabolism and Pharmacokinetics, Bristol-Myers Squibb Co., 5 Research Parkway, Wallingford, Connecticut 06492, Department of Oncology Drug Discovery, Department of Metabolism and Pharmacokinetics, Bristol-Myers Squibb Co., Route 206 and Province Line Rd, Princeton, New Jersey 08540

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm800832q

Reference24 articles.

1. Receptor tyrosine kinases: mechanisms of activation and signaling

2. Molecular Recognition of Protein Kinase Binding Pockets for Design of Potent and Selective Kinase Inhibitors

3. The insulin-like growth factor system and cancer

4. The IGF-1 receptor in cancer biology

5. Role of the Insulin-Like Growth Factor Family in Cancer Development and Progression

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