Fragment-Based Covalent Ligand Screening Enables Rapid Discovery of Inhibitors for the RBR E3 Ubiquitin Ligase HOIP-Reference-Cited by-同舟云学术

Fragment-Based Covalent Ligand Screening Enables Rapid Discovery of Inhibitors for the RBR E3 Ubiquitin Ligase HOIP

Published:2019-01-18 Issue:6 Volume:141 Page:2703-2712
ISSN:0002-7863
Container-title:Journal of the American Chemical Society
language:en
Short-container-title:J. Am. Chem. Soc.

Author:

Johansson Henrik¹²^ORCID,Isabella Tsai Yi-Chun²,Fantom Ken³,Chung Chun-Wa¹³,Kümper Sandra¹²,Martino Luigi²,Thomas Daniel A.³,Eberl H. Christian⁴,Muelbaier Marcel⁴^ORCID,House David¹^ORCID,Rittinger Katrin²^ORCID

Affiliation:

1. Crick-GSK Biomedical LinkLabs, GlaxoSmithKline, Gunnels Wood Road, Stevenage SG1 2NY, United Kingdom

2. Molecular Structure of Cell Signalling Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, United Kingdom

3. R&D Platform Technology & Science, GlaxoSmithKline, Gunnels Wood Road, Stevenage SG1 2NY, United Kingdom

4. Cellzome GmbH, a GlaxoSmithKline Company, Meyerhofstraße 1, Heidelberg 69117, Germany

Funder

Research Councils UK

Wellcome Trust

GlaxoSmithKline

Cancer Research UK

Publisher

American Chemical Society (ACS)

Subject

Colloid and Surface Chemistry,Biochemistry,General Chemistry,Catalysis

Link

http://pubs.acs.org/doi/pdf/10.1021/jacs.8b13193

Reference39 articles.

1. The Ubiquitin Code

2. Ubiquitin: structures, functions, mechanisms

3. Will the Ubiquitin System Furnish as Many Drug Targets as Protein Kinases?

4. Drugging the undruggables: exploring the ubiquitin system for drug development

5. A ubiquitin ligase complex assembles linear polyubiquitin chains

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