An Integrated Strategy for Assessing the Metabolic Stability and Biotransformation of Macrocyclic Peptides in Drug Discovery toward Oral Delivery-Reference-Cited by-同舟云学术

An Integrated Strategy for Assessing the Metabolic Stability and Biotransformation of Macrocyclic Peptides in Drug Discovery toward Oral Delivery

Published:2022-01-18 Issue:4 Volume:94 Page:2032-2041
ISSN:0003-2700
Container-title:Analytical Chemistry
language:en
Short-container-title:Anal. Chem.

Author:

Guo Yukuang¹,Ji Shaofei¹,Wang Wei¹,Wong Susan¹,Yen Chun-Wan¹,Hu Chloe¹,Leung Dennis H.¹,Plise Emile¹,Zhang Shu¹,Zhang Chenghong¹,Anene Uchenna A.¹,Zhang Donglu¹,Cunningham Christian N.¹^ORCID,Khojasteh S. Cyrus¹,Su Dian¹^ORCID

Affiliation:

1. Genentech, 1 DNA Way, South San Francisco, California 94080, United States

Publisher

American Chemical Society (ACS)

Subject

Analytical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.analchem.1c04008

Reference40 articles.

1. Peptide therapeutics: Targeting the undruggable space

2. Peptide therapeutics: current status and future directions

3. Peptide Therapeutics 2.0

4. Tools and rules for macrocycles

5. Orally Active Peptides: Is There a Magic Bullet?

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