Quantitative Metabolite Profiling of an Amino Group Containing Pharmaceutical in Human Plasma via Precolumn Derivatization and High-Performance Liquid Chromatography-Inductively Coupled Plasma Mass Spectrometry-Reference-Cited by-同舟云学术

Quantitative Metabolite Profiling of an Amino Group Containing Pharmaceutical in Human Plasma via Precolumn Derivatization and High-Performance Liquid Chromatography-Inductively Coupled Plasma Mass Spectrometry

Published:2017-01-13 Issue:3 Volume:89 Page:1907-1915
ISSN:0003-2700
Container-title:Analytical Chemistry
language:en
Short-container-title:Anal. Chem.

Author:

Li Sanwang¹,Klencsár Balázs¹,Balcaen Lieve¹,Cuyckens Filip²,Lynen Frederic³,Vanhaecke Frank¹^ORCID

Affiliation:

1. Department of Analytical Chemistry, Ghent University, Campus Sterre, Krijgslaan 281-S12, 9000 Ghent, Belgium

2. Pharmacokinetics, Dynamics & Metabolism, Janssen R&D, Turnhoutseweg 30, 2340 Beerse, Belgium

3. Department of Organic and Macromolecular Chemistry, Ghent University, Campus Sterre, Krijgslaan 281-S4-bis, 9000 Ghent, Belgium

Funder

China Scholarship Council

Bijzonder Onderzoeksfonds

Publisher

American Chemical Society (ACS)

Subject

Analytical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.analchem.6b04388

Reference63 articles.

1. Role of drug metabolism in drug discovery and development

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3. Current approaches and challenges for the metabolite profiling of complex natural extracts

4. Peer Reviewed: Systematic LC/MS Metabolite Identification in Drug Discovery

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