Enhanced Recognition of a Herbal Compound Epiberberine by a DNA Quadruplex-Duplex Structure

Author:

Zhan Xuan1,Deng Liping1,Lian Yun1,Shu Zhiyu2,Xu Yunong1,Mai Xinyi1,Krishna Manchugondanahalli S.2,Lu Rongguang1,Wang Anni1,Bai Shiyao1,Zhou Fangyu1,Xiong Chi3ORCID,Xu Yingyi4,Ni Jie1,Vandana J. Jeya56,Wang Zi1,Li Yuqing7,Sun Dongmei8,Huang Shaohui9,Liu Jingyan10,Cheng Gui-Juan1ORCID,Wu Song7ORCID,Chiang Ying-Chih1,Stjepanovic Goran1ORCID,Jiang Cheng1,Shao Yong11ORCID,Chen Gang112ORCID

Affiliation:

1. School of Medicine, The Chinese University of Hong Kong, Shenzhen (CUHK-Shenzhen), Shenzhen 518172, Guangdong, P. R. China

2. Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, 637371 Singapore

3. MinJiang Collaborative Center for Theoretical Physics, College of Physics and Electronic Information Engineering, Minjiang University, Fuzhou 350108, Fujian, P. R. China

4. LightEdge Technologies Ltd., Zhongshan 528400, Guangdong, P. R. China

5. Department of Surgery, Weill Cornell Medicine, New York, New York 10065, United States

6. Tri-Institutional PhD Program in Chemical Biology, Weill Cornell Medicine, Memorial Sloan Kettering Cancer Center, The Rockefeller University, New York, New York 10065, United States

7. Department of Urology, South China Hospital of Shenzhen University, Shenzhen 518111, Guangdong, P. R. China

8. Guangdong Yifang Pharmaceutical, Foshan 528244, Guangdong, P. R. China

9. School of Life Sciences, University of Chinese Academy of Sciences, Beijing 101499, P. R. China

10. School of Medicine, The Second Affiliated Hospital, The Chinese University of Hong Kong, Shenzhen 518172, Guangdong, P. R. China

11. Key Laboratory of the Ministry of Education for Advanced Catalysis Materials, College of Chemistry and Materials Science, Zhejiang Normal University, Jinhua 321004, Zhejiang, P. R. China

12. Shenzhen Key Laboratory of Innovative Drug Synthesis, The Chinese University of Hong Kong, Shenzhen 518172, P. R. China

Funder

State Administration of Foreign Experts Affairs

Chinese University of Hong Kong, Shenzhen

Basic and Applied Basic Research Foundation of Guangdong Province

National Natural Science Foundation of China

Shenzhen Key Laboratory Fund

Leading Talent Program of Science and Technology Innovation in Zhejiang

Ganghong Young Scholar Development Fund

Shenzhen-Hong Kong Cooperation Zone for Technology and Innovation

Publisher

American Chemical Society (ACS)

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