A Supramolecular Biosensor for Rapid and High-Throughput Quantification of a Disease-Associated Niacin Metabolite

Author:

Ueno Masaya12ORCID,Sugiyama Hiroki1,Li Feng2ORCID,Nishimura Tatsuya23ORCID,Arakawa Hiroshi4,Chen Xi1,Cheng Xiaoxiao23,Takeuchi Shinji25,Takeshita Yumie6,Takamura Toshinari6,Miyagi Sakae7,Toyama Tadashi78,Soga Tomoyoshi9ORCID,Masuo Yusuke4,Kato Yukio4ORCID,Nakamura Hiroyuki10,Tsujiguchi Hiromasa10,Hara Akinori10,Tajima Atsushi11ORCID,Noguchi-Shinohara Moeko12,Ono Kenjiro12ORCID,Kurayoshi Kenta1,Kobayashi Masahiko1,Tadokoro Yuko12,Kasahara Atsuko1213,Shoulkamy Mahmoud I.1214ORCID,Maeda Katsuhiro23ORCID,Ogoshi Tomoki215ORCID,Hirao Atsushi12

Affiliation:

1. Division of Molecular Genetics, Cancer and Stem Cell Research Program, Cancer Research Institute, Kanazawa University, Kakuma-machi, Kanazawa, Ishikawa 920-1192, Japan

2. WPI Nano Life Science Institute (WPI-Nano LSI), Kanazawa University, Kakuma-machi, Kanazawa, Ishikawa 920-1192, Japan

3. Graduate School of Natural Science and Technology, Kanazawa University, Kakuma-machi, Kanazawa, Ishikawa 920-1192, Japan

4. Faculty of Pharmacy, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Ishikawa 920-1192, Japan

5. Division of Medical Oncology Cancer Research Institute, Kanazawa University, 13-1 Takaramachi, Kanazawa, Ishikawa 920-8640, Japan

6. Department of Endocrinology and Metabolism, Kanazawa University Graduate School of Medical Sciences, 13-1 Takara-machi, Kanazawa, Ishikawa 920-8640, Japan

7. Innovative Clinical Research Center, Kanazawa University, 13-1 Takaramachi, Kanazawa, Ishikawa 920-8640, Japan

8. Department of Nephrology, Faculty of Medical Sciences, University of Fukui, Yoshida-gun, Fukui 910-1193, Japan

9. Institute for Advanced Biosciences, Keio University, 246-2 Kakuganji-mizukami, Tsuruoka, Yamagata 997-0052, Japan

10. Department of Hygiene and Public Health, Faculty of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, 13-1 Takaramachi, Kanazawa, Ishikawa 920-8640, Japan

11. Department of Bioinformatics and Genomics, Graduate School of Advanced Preventive Medical Sciences, Kanazawa University, 13-1 Takara-machi, Kanazawa, Ishikawa 920-8640, Japan

12. Department of Neurology, Kanazawa University Graduate School of Medical Sciences, 13-1 Takara-machi, Kanazawa, Ishikawa 920-1192, Japan

13. Institute for Frontier Science Initiative, Kanazawa University, Kakuma-machi, Kanazawa, Ishikawa 920-1192, Japan

14. Zoology Department, Faculty of Science, Minia University, El-Minia 61519, Egypt

15. Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University, Kyoto 615-8510, Japan

Funder

Ministry of Education, Culture, Sports, Science and Technology

Japan Agency for Medical Research and Development

Kanazawa University

Japan Science and Technology Corporation

Publisher

American Chemical Society (ACS)

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