Rapid Identification of Disulfide Bonds and Cysteine-Related Variants in an IgG1 Knob-into-Hole Bispecific Antibody Enhanced by Machine Learning
Author:
Affiliation:
1. Genentech, 1 DNA Way, South San Francisco, California 94080, United States
Publisher
American Chemical Society (ACS)
Subject
Analytical Chemistry
Link
https://pubs.acs.org/doi/pdf/10.1021/acs.analchem.8b04071
Reference50 articles.
1. Alternative molecular formats and therapeutic applications for bispecific antibodies
2. ‘Knobs-into-holes’ engineering of antibody CH3 domains for heavy chain heterodimerization
3. Disulfide Linkage Characterization of Disulfide Bond-Containing Proteins and Peptides by Reducing Electrochemistry and Mass Spectrometry
4. Bispecific antibody process development: Assembly and purification of knob and hole bispecific antibodies
5. Killing of human leukaemia/lymphoma B cells by activated cytotoxic T lymphocytes in the presence of a bispecific monoclonal antibody (αCD3/αCD19)
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3. Comprehensive Stress Stability Studies Reveal the Prominent Stability of the Liquid-Formulated Biotherapeutic Asymmetric Monovalent Bispecific IgG1 Monoclonal Antibody Format;Journal of Pharmaceutical Sciences;2024-08
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