High-Throughput Analyses of Therapeutic Antibodies Using High-Field Asymmetric Waveform Ion Mobility Spectrometry Combined with SampleStream and Intact Protein Mass Spectrometry-Reference-Cited by-同舟云学术

High-Throughput Analyses of Therapeutic Antibodies Using High-Field Asymmetric Waveform Ion Mobility Spectrometry Combined with SampleStream and Intact Protein Mass Spectrometry

Published:2023-11-13 Issue:47 Volume:95 Page:17263-17272
ISSN:0003-2700
Container-title:Analytical Chemistry
language:en
Short-container-title:Anal. Chem.

Author:

Shi Rachel Liuqing¹^ORCID,Dillon Michael A.²,Compton Philip D.³,Sawyer William S.¹,Thorup John R.¹,Kwong Mandy¹,Chan Pamela¹,Chiu Cecilia P. C.²,Li Ran⁴,Yadav Rajbharan⁴,Lee Genee Y.⁵,Gober Joshua G.⁶,Li Zhiyu⁷,ElSohly Adel M.⁶^ORCID,Ovacik Ayse Meric⁴,Koerber James T.²,Spiess Christoph²^ORCID,Josephs Jonathan L.¹,Tran John C.¹

Affiliation:

1. Department of Biochemical and Cellular Pharmacology, Genentech, Inc., South San Francisco, California 94080, United States

2. Department of Antibody Engineering, Genentech, Inc., South San Francisco, California 94080, United States

3. Integrated Protein Technologies, Evanston, Illinois 60201, United States

4. Department of Preclinical and Translational Pharmacokinetics and Pharmacodynamics, Genentech Inc., South San Francisco, California 94080, United States

5. Department of Molecular Oncology, Genentech Inc., South San Francisco, California 94080, United States

6. Department of Protein Chemistry, Genentech Inc., South San Francisco, California 94080, United States

7. The DMPK Service Department, WuXi AppTec Inc., Shanghai 200131, China

Funder

Genentech

Publisher

American Chemical Society (ACS)

Subject

Analytical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.analchem.3c03158

Reference70 articles.

1. Antibodies to watch in 2023

2. Development of therapeutic antibodies for the treatment of diseases

3. Next generation antibody drugs: pursuit of the 'high-hanging fruit'

4. Therapeutic antibodies for autoimmunity and inflammation

5. Preparation of Bispecific Antibodies by Chemical Recombination of Monoclonal Immunoglobulin G 1 Fragments