DNA-Dependent Protein Kinase (DNA-PK) Inhibitors. Synthesis and Biological Activity of Quinolin-4-one and Pyridopyrimidin-4-one Surrogates for the Chromen-4-one Chemotype-Reference-Cited by-同舟云学术

DNA-Dependent Protein Kinase (DNA-PK) Inhibitors. Synthesis and Biological Activity of Quinolin-4-one and Pyridopyrimidin-4-one Surrogates for the Chromen-4-one Chemotype

Published:2010-11-16 Issue:24 Volume:53 Page:8498-8507
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Cano Céline¹,Barbeau Olivier R.¹,Bailey Christine²,Cockcroft Xiao-Ling²,Curtin Nicola J.¹,Duggan Heather²,Frigerio Mark²,Golding Bernard T.¹,Hardcastle Ian R.¹,Hummersone Marc G.²,Knights Charlotte²,Menear Keith A.²,Newell David R.¹,Richardson Caroline J.²,Smith Graeme C. M.²,Spittle Ben²,Griffin Roger J.¹

Affiliation:

1. Newcastle Cancer Centre, Northern Institute for Cancer Research, School of Chemistry, Bedson Building, Newcastle University, Newcastle upon Tyne, NE1 7RU, United Kingdom

2. KuDOS Pharmaceuticals, Ltd., 410 Cambridge Science Park, Milton Road, Cambridge, CB4 0PE, United Kingdom

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm100608j

Reference19 articles.

1. The DNA-damage response in human biology and disease

2. The DNA-dependent protein kinase

3. Requirement for the Kinase Activity of Human DNA-Dependent Protein Kinase Catalytic Subunit in DNA Strand Break Rejoining

4. ATM: from gene to function

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