Discovery of 7-Tetrahydropyran-2-yl Chromans: β-Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) Inhibitors That Reduce Amyloid β-Protein (Aβ) in the Central Nervous System
Author:
Affiliation:
1. Array BioPharma, 3200 Walnut Street, Boulder, Colorado 80301, United States
2. Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States
Publisher
American Chemical Society (ACS)
Subject
Drug Discovery,Molecular Medicine
Link
https://pubs.acs.org/doi/pdf/10.1021/jm401635n
Reference59 articles.
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3. Alzheimer's disease: strategies for disease modification
4. The Amyloid Hypothesis of Alzheimer's Disease: Progress and Problems on the Road to Therapeutics
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