Synthesis of Novel GABA Uptake Inhibitors. 4. Bioisosteric Transformation and Successive Optimization of Known GABA Uptake Inhibitors Leading to a Series of Potent Anticonvulsant Drug Candidates-Reference-Cited by-同舟云学术

Synthesis of Novel GABA Uptake Inhibitors. 4. Bioisosteric Transformation and Successive Optimization of Known GABA Uptake Inhibitors Leading to a Series of Potent Anticonvulsant Drug Candidates

Published:1999-09-24 Issue:21 Volume:42 Page:4281-4291
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Andersen Knud Erik¹,Sørensen Jan L.¹,Huusfeldt Per O.¹,Knutsen Lars J. S.¹,Lau Jesper¹,Lundt Behrend F.¹,Petersen Hans¹,Suzdak Peter D.¹,Swedberg Michael D. B.¹

Affiliation:

1. Health Care Discovery, Novo Nordisk A/S, Novo Nordisk Park, DK 2760 Måløv, Denmark

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm980492e

Reference66 articles.

1. Enna, S. J. Biochemistry, Anatomy, and Pharmacology of GABA Neurons. InPsychopharmacology: The Third Generation of Progress;Melzer, H. Y., Ed.; Raven Press: New York, 1987; pp 265−278.

2. Lloyd, K. G.; Morselli, P. L. Biochemistry, Anatomy, and Pharmacology of GABA Neurons. InPsychopharmacology: The Third Generation ofProgress;Melzer, H. Y., Ed.; Raven Press: New York, 1983; pp 183−201.

3. GABA synaptic mechanisms: Stereochemical and conformational requirements

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