Discovery and Biological Evaluation of 5-Aryl-2-furfuramides, Potent and Selective Blockers of the Nav1.8 Sodium Channel with Efficacy in Models of Neuropathic and Inflammatory Pain-Reference-Cited by-同舟云学术

Discovery and Biological Evaluation of 5-Aryl-2-furfuramides, Potent and Selective Blockers of the Nav1.8 Sodium Channel with Efficacy in Models of Neuropathic and Inflammatory Pain

Published:2008-01-05 Issue:3 Volume:51 Page:407-416
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Kort Michael E.¹,Drizin Irene¹,Gregg Robert J.¹,Scanio Marc J. C.¹,Shi Lei¹,Gross Michael F.¹,Atkinson Robert N.¹,Johnson Matthew S.¹,Pacofsky Gregory J.¹,Thomas James B.¹,Carroll William A.¹,Krambis Michael J.¹,Liu Dong¹,Shieh Char-Chang¹,Zhang XuFeng¹,Hernandez Gricelda¹,Mikusa Joseph P.¹,Zhong Chengmin¹,Joshi Shailen¹,Honore Prisca¹,Roeloffs Rosemarie¹,Marsh Kennan C.¹,Murray Bernard P.¹,Liu Jinrong¹,Werness Stephen¹,Faltynek Connie R.¹,Krafte Douglas S.¹,Jarvis Michael F.¹,Chapman Mark L.¹,Marron Brian E.¹

Affiliation:

1. Global Pharmaceutical Research and Development, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, Illinois 60064-6100, and Icagen, Inc., 4222 Emperor Boulevard, Durham, North Carolina 27703

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm070637u

Reference54 articles.

1. Medicinal Chemistry of Neuronal Voltage-Gated Sodium Channel Blockers

2. Nomenclature of Voltage-Gated Sodium Channels

3. International Union of Pharmacology. XLVII. Nomenclature and Structure-Function Relationships of Voltage-Gated Sodium Channels

4. From Ionic Currents to Molecular Mechanisms

5. Voltage-Gated Sodium Channels and Hyperalgesia

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