2′-Deoxy Cyclic Adenosine 5′-Diphosphate Ribose Derivatives: Importance of the 2′-Hydroxyl Motif for the Antagonistic Activity of 8-Substituted cADPR Derivatives-Reference-Cited by-同舟云学术

2′-Deoxy Cyclic Adenosine 5′-Diphosphate Ribose Derivatives: Importance of the 2′-Hydroxyl Motif for the Antagonistic Activity of 8-Substituted cADPR Derivatives

Published:2008-02-28 Issue:6 Volume:51 Page:1623-1636
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Zhang Bo¹,Wagner Gerd K.¹,Weber Karin¹,Garnham Clive¹,Morgan Anthony J.¹,Galione Antony¹,Guse Andreas H.¹,Potter Barry V. L.¹

Affiliation:

1. Wolfson Laboratory of Medicinal Chemistry, University of Bath, Department of Pharmacy and Pharmacology, Claverton Down, Bath, BA2 7AY, United Kingdom, The Calcium Signaling Group, Institute of Biochemistry and Molecular Biology I: Cellular Signal Transduction, Center of Experimental Medicine, University Medical Center Hamburg−Eppendorf, Martinistrasse 52, D-20246 Hamburg, Germany, and Department of Pharmacology, University of Oxford, Mansfield Road, Oxford OX1 3QT, United Kingdom

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm7010386

Reference59 articles.

1. Pyridine nucleotide metabolites stimulate calcium release from sea urchin egg microsomes desensitized to inositol trisphosphate.

2. Novel mechanism of intracellular calcium release in pituitary cells.

3. Comparison of Ca2+ mobilizing activities of cyclic ADP-ribose and inositol trisphosphate.

4. Second messenger function and the structure-activity relationship of cyclic adenosine diphosphoribose (cADPR)

5. Medicinal Chemistry and Pharmacology of Cyclic ADP-Ribose

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