Structural Basis for Inhibition of Mycobacterial and Human Adenosine Kinase by 7-Substituted 7-(Het)aryl-7-deazaadenine Ribonucleosides

Author:

Snášel Jan1,Nauš Petr1,Dostál Jiří1,Hnízda Aleš1,Fanfrlík Jindřich1,Brynda Jiří1,Bourderioux Aurelie1,Dušek Michal2,Dvořáková Hana3,Stolaříková Jiřina4,Zábranská Helena1,Pohl Radek1,Konečný Petr5,Džubák Petr5,Votruba Ivan1,Hajdúch Marián5,Řezáčová Pavlína1,Veverka Václav1,Hocek Michal1,Pichová Iva1

Affiliation:

1. Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, Flemingovo nam. 2, 16610 Prague 6, Czech Republic

2. Institute of Physics ASCR, v.v.i., Na Slovance 2, 182 21 Praha 8, Czech Republic

3. Laboratory of NMR Spectroscopy, Institute of Chemical Technology, Technicka 5, 16628 Prague 6, Czech Republic

4. Laboratory for Mycobacterial Diagnostics and Tuberculosis, Regional Institute of Public Health in Ostrava, Partyzánské nám. 7, 70200 Ostrava, Czech Republic

5. Institute of Molecular and Translational Medicine, Faculty of Medicine and Dentistry, Palacky University and University Hospital in Olomouc, Hněvotínská 5, 77515 Olomouc, Czech Republic

Funder

European Commission

Ministry of Education, Youth and Sports

Czech Science Foundation

Akademie ved Ceské Republiky

Gilead Sciences

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

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