Condensation of Macrocyclic Polyketides Produced by Penicillium sp. DRF2 with Mercaptopyruvate Represents a New Fungal Detoxification Pathway

Author:

de Castro Marcos V.1,Ióca Laura P.1,Williams David E.2,Costa Bruna Z.3,Mizuno Carolina M.14,Santos Mario F. C.1,de Jesus Karen1,Ferreira Éverton L. F.1,Seleghim Mirna H. R.4,Sette Lara D.5,Pereira Filho Edenir R.6,Ferreira Antonio G.6,Gonçalves Natália S.7,Santos Raquel A.7,Patrick Brian O.8,Andersen Raymond J.2,Berlinck Roberto G. S.1

Affiliation:

1. Instituto de Quimica de São Carlos, Universidade de São Paulo, CP 780, CEP 13560-970, São Carlos, SP, Brazil

2. Departments of Chemistry and Earth, Ocean & Atmospheric Sciences, University of British Columbia, Vancouver, BC V6T 1Z1, Canada

3. Instituto de Quimica, Universidade Estadual de Campinas, Caixa Postal 6154, CEP 13083-970, Campinas, SP, Brazil

4. Departamento de Ecologia e Biologia Evolutiva, Universidade Federal de São Carlos, São Carlos, SP, Brazil

5. Departamento de Bioquímica e Microbiologia, Instituto de Biociências, Universidade Estadual Paulista “Júlio de Mesquita Filho”, Campus Rio Claro, Avenida 24-A, 1515, Rio Claro, SP, Brazil

6. Departamento de Química, Universidade Federal de São Carlos, CEP 13565-905, São Carlos, SP, Brazil

7. Laboratório de Genética e Biologia Molecular, Universidade de Franca, Avenida Dr. Armando Salles Oliveira, 201. Pq. Universitário, Franca, SP, Brazil

8. Department of Chemistry, University of British Columbia, Vancouver, BC V6T 1Z1, Canada

Funder

Conselho Nacional de Desenvolvimento Científico e Tecnológico

Fundação de Amparo à Pesquisa do Estado de São Paulo

Natural Sciences and Engineering Research Council of Canada

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior

National Science Foundation

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Complementary and alternative medicine,Drug Discovery,Pharmaceutical Science,Pharmacology,Molecular Medicine,Analytical Chemistry

Reference63 articles.

1. Secondary metabolic gene clusters: evolutionary toolkits for chemical innovation

2. Cox, R. J.; Simpson, T. J.InComprehensive Natural Products Chemistry;Meth-Cohn, O.; Barton, S. D.; Nakanishi, K., Eds.Elsevier:Amsterdam, 1999; Vol.I, pp347–383.

3. Hanson, J. R.The Chemistry of Fungi;RSC Publishing:Cambridge, UK, 2008; pp47–72.

4. Polyketides, proteins and genes in fungi: programmed nano-machines begin to reveal their secrets

5. Recent progress regarding the bioactivities, biosynthesis and synthesis of naturally occurring resorcinolic macrolides

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