Mechanistic Insights into the Leishmanicidal and Bactericidal Activities of Batroxicidin, a Cathelicidin-Related Peptide from a South American Viper (Bothrops atrox)

Author:

Dematei Anderson12,Nunes João B.23,Moreira Daniel C.2ORCID,Jesus Jéssica A.4,Laurenti Márcia D.5,Mengarda Ana C. A.6,Vieira Maria Silva78,do Amaral Constança Pais9,Domingues Marco M.9,de Moraes Josué6ORCID,Passero Luiz F. D.45,Brand Guilherme3ORCID,Bessa Lucinda J.10,Wimmer Reinhard11ORCID,Kuckelhaus Selma A. S.2,Tomás Ana M.7812,Santos Nuno C.9,Plácido Alexandra10,Eaton Peter1013,Leite José Roberto S. A.12ORCID

Affiliation:

1. Center for Tropical Medicine, NMT, Faculty of Medicine, University of Brasilia, Brasília 70910-900, Brazil

2. Research Center in Morphology and Applied Immunology, NuPMIA, Faculty of Medicine, University of Brasilia, Brasília 70910-900, Brazil

3. Laboratory for the Synthesis and Analysis of Biomolecules, LSAB, Institute of Chemistry, University of Brasilia, Brasília 70910-900, Brazil

4. Institute of Biosciences, São Paulo State University, São Paulo, Brazil

5. Department of Pathology, Laboratory of Pathology of Infectious Diseases, Faculty of Medicine, University of São Paulo, São Paulo 05508-060, Brazil

6. Research Center on Neglected Diseases, NPDN, University of Guarulhos, Guarulhos 07023-070, Brazil

7. I3S, Institute of Research and Innovation in Health, University of Porto, Porto 4099-002, Portugal

8. IBMC, Institute of Molecular and Cellular Biology, University of Porto, Porto 4099-002, Portugal

9. Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, 1649-028 Lisbon, Portugal

10. LAQV/REQUIMTE, Department of Chemistry and Biochemistry, Faculty of Sciences of the University of Porto, Porto 4099-002, Portugal

11. Department of Chemistry and Bioscience, Aalborg University, Aalborg 9220, Denmark

12. ICBAS, Abel Salazar Institute for Biomedical Research, University of Porto, Porto 4099-002, Portugal

13. The Bridge, Joseph Banks Laboratories, School of Chemistry, University of Lincoln, Lincoln LN6 7TS, U.K.

Funder

Funda??o de Apoio ? Pesquisa do Distrito Federal

European Regional Development Fund

Conselho Nacional de Desenvolvimento Cient?fico e Tecnol?gico

Funda??o de Amparo ? Pesquisa do Estado de S?o Paulo

Funda??o para a Ci?ncia e a Tecnologia

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Complementary and alternative medicine,Drug Discovery,Pharmaceutical Science,Pharmacology,Molecular Medicine,Analytical Chemistry

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