Contemporary Approaches to the Discovery and Development of Broad-Spectrum Natural Product Prototypes for the Control of Coronaviruses

Author:

Hanna George S.1ORCID,Choo Yeun-Mun2,Harbit Ryan3,Paeth Heather1,Wilde Sarah4,Mackle James5,Verga Jacopo-Umberto5,Wolf Bethany J.6,Thomas Olivier P.7ORCID,Croot Peter8ORCID,Cray James9,Thomas Courtney10,Li Ling-Zhi11ORCID,Hardiman Gary5ORCID,Hu Jin-Feng12ORCID,Wang Xiaojuan13,Patel Dharmeshkumar14,Schinazi Raymond F.14ORCID,O’Keefe Barry R.15ORCID,Hamann Mark T.1

Affiliation:

1. Departments of Drug Discovery and Biomedical Sciences and Public Health, Colleges of Pharmacy and Medicine, Medical University of South Carolina, Charleston, South Carolina 29425, United States

2. Department of Chemistry, University of Malaya, Kuala Lumpur 50603, Malaysia

3. College of Charleston, Charleston, South Carolina 29425, United States

4. Department of Biology, Clemson University, Clemson, South Carolina 29631, United States

5. School of Biological Sciences & Institute for Global Food Security, Queens University, Belfast, Northern Ireland BT7 1NN, United Kingdom

6. Department of Public Health Sciences, Medical University of South Carolina, Charleston, South Carolina 29425, United States

7. Marine Biodiscovery, School of Chemistry and Ryan Institute, National University of Ireland Galway, Galway H91Tk33, Ireland

8. Irish Centre for Research in Applied Geoscience, Earth and Ocean Sciences and Ryan Institute, School of Natural Sciences, National University of Ireland, Galway, Galway H91Tk33, Ireland

9. Department of Biomedical Education and Anatomy, College of Medicine and Division of Biosciences, College of Dentistry, The Ohio State University, Columbus, Ohio 43210, United States

10. Department of Chemistry, South Carolina State University, Orangeburg, South Carolina 29117, United States

11. School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University/SPU, Shenyang 110016, China

12. School of Advanced Study, Zhejiang Provincial Key Laboratory of Plant Ecology and Conservation, Taizhou University, Zhejiang 318000, China

13. School of Pharmacy, Lanzhou University, Lanzhou 730300, China

14. Department of Pediatrics, Laboratory of Biochemical Pharmacology, Emory University School of Medicine, and Children’s Healthcare of Atlanta, Atlanta, Georgia 30322, United States

15. Molecular Targets Program, Center for Cancer Research, Natural Products Branch, Developmental Therapeutics Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute, Frederick, Maryland 21702, United States

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Complementary and alternative medicine,Drug Discovery,Pharmaceutical Science,Pharmacology,Molecular Medicine,Analytical Chemistry

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