Rational Design and Synthesis of Novel Dimeric Diketoacid-Containing Inhibitors of HIV-1 Integrase: Implication for Binding to Two Metal Ions on the Active Site of Integrase-Reference-Cited by-同舟云学术

Rational Design and Synthesis of Novel Dimeric Diketoacid-Containing Inhibitors of HIV-1 Integrase: Implication for Binding to Two Metal Ions on the Active Site of Integrase

Published:2004-04-10 Issue:10 Volume:47 Page:2561-2573
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Long Ya-Qiu¹,Jiang Xiao-Hua¹,Dayam Raveendra¹,Sanchez Tino¹,Shoemaker Robert¹,Sei Shizuko¹,Neamati Nouri¹

Affiliation:

1. State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, CAS, 555 Zuchongzhi Road, Shanghai 201203, China, Laboratory of Antiviral Drug Mechanisms, SAIC−Frederick, Screening Technologies Branch, DTP, DCTD, National Cancer Institute at Frederick, Frederick, Maryland 21702, and Department of Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles, California 90089

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm030559k

Reference48 articles.

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2. Strategies in the design of antiviral drugs

3. HIV chemotherapy

4. Patented small molecule inhibitors of HIV-1 integrase: a 10-year saga

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