Calculation of Lipophilicity of a Large, Diverse Dataset of Anticancer Platinum Complexes and the Relation to Cellular Uptake-Reference-Cited by-同舟云学术

Calculation of Lipophilicity of a Large, Diverse Dataset of Anticancer Platinum Complexes and the Relation to Cellular Uptake

Published:2007-09-27 Issue:21 Volume:50 Page:5227-5237
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Oldfield Steven P.¹,Hall Matthew D.¹,Platts James A.¹

Affiliation:

1. School of Chemistry, Cardiff University, Park Place, Cardiff CF10 3AT, U.K., and Laboratory of Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm0708275

Reference44 articles.

1. Hydrophobicity and Central Nervous System Agents: On the Principle of Minimal Hydrophobicity in Drug Design

2. Modeling oil—water partitioning and membrane permeation using reversed-phase chromatography

3. Determination of hydrophobic parameters by reversed-phase liquid chromatography: theory, experimental techniques, and application in studies on quantitative structure-activity relationships

4. Relationships between hydrophobicity, reactivity, accumulation and peripheral nerve toxicity of a series of platinum drugs

5. The influence of structure on the activity and toxicity of Pt anti-cancer drugs

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