Platform Reagents Enable Synthesis of Ligand-Directed Covalent Probes: Study of Cannabinoid Receptor 2 in Live Cells

Author:

Kosar Miroslav1ORCID,Sykes David A.23,Viray Alexander E. G.4ORCID,Vitale Rosa Maria5ORCID,Sarott Roman C.1ORCID,Ganzoni Rudolf L.1ORCID,Onion David6,Tobias Janelle M.4,Leippe Philipp7,Ullmer Christoph8,Zirwes Elisabeth A.8,Guba Wolfgang8ORCID,Grether Uwe8,Frank James A.49ORCID,Veprintsev Dmitry B.23ORCID,Carreira Erick M.1ORCID

Affiliation:

1. Laboratorium für Organische Chemie, Eidgenössische Technische Hochschule Zürich, Vladimir-Prelog-Weg 3, 8093 Zürich, Switzerland

2. Centre of Membrane Proteins and Receptors (COMPARE), University of Birmingham and University of Nottingham, Midlands, Nottingham NG7 2UH, U.K.

3. Faculty of Medicine & Health Sciences, University of Nottingham, Nottingham NG7 2UH, U.K.

4. Department of Chemical Physiology & Biochemistry, Oregon Health & Science University, Portland, Oregon 97239-3098, United States

5. Institute of Biomolecular Chemistry, National Research Council (ICB-CNR), Via Campi Flegrei 34, 80078 Pozzuoli, Italy

6. School of Life Sciences, University of Nottingham, Nottingham NG7 2UH, U.K.

7. Department of Chemical Biology, Max Planck Institute for Medical Research, Jahnstr. 29, 69120 Heidelberg, Germany

8. Roche Pharma Research & Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., 4070 Basel, Switzerland

9. Vollum Institute, Oregon Health & Science University, Portland, Oregon 97239-3098, United States

Funder

Instituto Nazionale di Fisica Nucleare

Universit? degli Studi di Napoli Federico II

Consiglio Nazionale delle Ricerche

Publisher

American Chemical Society (ACS)

Subject

Colloid and Surface Chemistry,Biochemistry,General Chemistry,Catalysis

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